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Why does FPi work ?

Independent research over the past 14 years have uncovered many digestion nuances AgriBusinessWeek.com provided a great summary of Peptide discoveries in a January, 2009 article as follows:

"Traditionally, it was thought that all dietary proteins needed to be hydrolyzed to free AA in order to be absorbed. This concept was however challenged when the first intestinal oligopeptide transporter, PepTi, was simultaneously cloned and identified by two separate groups in rats and rabbits (Bollet al., 1994; Fei et al., 1994). The peptide transporter was then identified and characterized in domestic animals such as pigs (Klang et al., 2005), chickens (Chen et al., 1999), turkey (Van etal., 2005), and ruminant animals (Chen et al., 1999). The PepTi protein, which was found to be located at the brush border membrane of intestinal epithelial cells (Leibach and Ganapathy, 1996), has been shown to have broad substrate specificity, compared to the relatively narrow substrates specificity of most free AA transporters.

Furthermore, a wide range of di- or tri-peptides, regardless of their molecular weight, electrical charge and hydrophobicity could be transported by PepT1, demonstrating the importance of peptide transport in domestic animals (Pan et al., 2001; Chen et al., 2002; Adibi, 2003). Indeed, the absorption of intact peptides from the gastrointestinal tract appears to constitute part of the end products of dietary protein entering the blood (Pan et al., 1998)"